Kosin Medical Journal

Original articles

The solid predominant subtype as an independent risk factor for recurrence in patients with pathologic stage I lung adenocarcinoma: Chul Ho Lee, Yun-Ho Jeon; Kosin Med J. 2023;38(2):117-125. Published online June 8, 2023; DOI: https://doi.org/10.7180/kmj.23.103

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Abstract PDF PubReader ePub: Background
Increasingly many patients have been diagnosed with stage I adenocarcinoma due to the use of low-dose chest computed tomography for lung cancer screening. Therefore, this study aimed to analyze tumor recurrence based on the predominant subtype in patients with stage I lung adenocarcinoma who underwent lobectomy.
Methods
We retrospectively analyzed 114 patients who underwent lobectomy for pathologic stage I lung adenocarcinoma from June 2001 to July 2019.
Results
In univariate analyses, significant factors were current smoking at the time of surgery (p=0.029), pathologic tumor size (p=0.006), central tumor location (p=0.003), maximum standardized uptake value on positron emission tomography-computed tomography (p=0.001), and the solid predominant subtype (p=0.012). In the multivariate analysis, only the solid predominant subtype (hazard ratio, 9.702; 95% confidence interval, 1.179–79.874; p=0.035) was an independent risk factor.
Conclusions
If the solid subtype is predominant in pathologic findings, adjuvant chemotherapy after standard surgical resection may be considered to help reduce the risk of tumor recurrence and increase survival.

Incidence of arterial steno-occlusive disease and related factors in patients undergoing coronary artery bypass graft surgery: Seong Gyu Kim, Geun Woo Lee, Chul Ho Lee; Kosin Med J. 2022;37(2):140-145. Published online June 24, 2022; DOI: https://doi.org/10.7180/kmj.22.104

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Background
Patients who undergo coronary artery bypass graft (CABG) surgery receive regular physical examinations and medications on an outpatient basis. However, these patients are at risk of developing other vascular diseases, such as postoperative arterial steno-occlusive disease (SOD). This study investigated the incidence of SOD and related factors.
Methods
In total, 246 patients who underwent CABG surgery from January 1, 2017 to December 31, 2021 were investigated. The incidence and risk factors of vascular disease were analyzed by dividing the included patients into SOD and non-SOD groups. Laboratory tests, medical history, surgical information, and family history were investigated through an electronic chart review.
Results
Data from 193 patients who met the criteria were analyzed. SOD occurred in 19.1% of patients, and the cerebral artery (38%) was the most common artery involved, followed by the peripheral artery (32%), the coronary artery (22%), and the retinal artery (8%). Risk factors for the development of SOD included estimated glomerular filtration rate (eGFR; odds ratio [OR]=0.977, p=0.008), cholesterol (OR=1.020, p=0.001), and patients with diabetes complications (OR=5.077, p=0.010). The 3-year cumulative incidence rate was 21.6%, and the risk factors for cumulative occurrence were a low eGFR, elevated cholesterol, and complications of diabetes.
Conclusions
Low eGFR, high cholesterol, and the presence of diabetic complications before CABG surgery may be associated with postoperative vascular disease. In these cases, close monitoring, proper drug administration, and patient warnings may be required.

Citations

Citations to this article as recorded by

Why should you not overlook the postoperative evaluation of steno-occlusive arterial disease for coronary artery bypass graft patients?
Jong Hyun Baek, Haeyoung Lee
Kosin Medical Journal.2022; 37(2): 93. CrossRef

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